Mucoepidermoid carcinoma in warthin tumor of the parotid gland. Mucoepidermoid carcinoma is more frequent in females, occurs in the fifth decade of life and is usually found in the parotid gland. Mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands among children and adults and shows a wide, nearly uniform age distribution, with diminution in pediatric and geriatric life. Mc is defined as a malignant epithelial neoplasm of the salivary glands 3 that represents 3040 % of all malignant neoplasms of the salivary glands 4.
Ataxia telangiectasia and mucoepidermoid carcinoma of the parotid gland. However, mec is the most common malignant tumour of the salivary glands with the majority originating from the parotid gland. For accreditation purposes, this protocol should be used for the following procedures and tumor types. Approximately 25 percent of parotid tumors are cancerous malignant. Mucoepidermoid carcinoma of the parotid gland with ovarian. Mucoepidermoid carcinoma variants adenoid cystic carcinoma carcinoma ex pleomorphic adenoma salivary duct carcinoma mucoepidermoid carcinoma incidence most common malignant salivary gland tumor children and adults major and minor salivary glands p k i id 5th t 6th d d 36 peak incidence 5th to 6th decades. Mucoepidermoid carcinoma the oral cancer foundation.
Mucoepidermoid carcinoma of the parotid gland in children. All but one were located within the parotid gland and none were within the pps nor me tastatic at presentation. Majority of the salivary gland tumors arise in parotid gland with maximum. Mucoepidermoid carcinoma is the most common malignant tumor of salivary gland. Mar 25, 2006 this biopsy result shows low grade mucoepidermoid carcinoma of the right parotid gland and the ent has suggested to completely remove the right parotid gland.
Cancer in the salivary gland is called salivary gland cancer. This protocol can be utilized for a variety of procedures and tumor types for clinical care purposes. Approximately 80% of parotid gland tumors are benign. These cancers are usually low grade, but they can also be intermediate or high grade. Mucoepidermoid carcinoma mec, one of the most common salivary gland malignancies, is rare in children. Mucoepidermoid carcinoma of the salivary glands in brazil scielo. Presents as painless, slowgrowing mass that is firm or hard. Mucoepidermoid carcinoma genetic and rare diseases. Complete excision superficial or total parotidectomy with preservation of facial nerve is the treatment of choice. Clinical, histological, and radiological findings of palatal mec in a 12yearold girl are presented with threeyear followup. Dec 11, 2002 malignant transformation of warthins tumor is extremely rare, although it is the second most common benign tumor of the parotid gland. Mucoepidermoid carcinomas represent a distinct type of tumor. We report a case of mec arising in wt of the parotid gland, describing clinical and pathological aspects.
Highgrade mucoepidermoid carcinoma expleomorphic adenoma of. Mucoepidermoid carcinoma is an unusual variant of thymic carcinoma characterized by the admixture of squamous and glandular, mucinsecreting elements, similar to their salivary gland counterparts. Protocol for the examination of specimens from patients with carcinomas of the major salivary glands. Among the major salivary glands, mec occurs most frequently in the parotid gland. However, it is the most common malignant salivary gland tumor of childhood 45. This is so far described only in the adult age group, and only one patient has been reported in the pediatric age group until today. The tumor is composed of epidermoid and mucin producing cells, which take origin from the duct epithelial lining. In the salivary glands, the most frequently occurring benign tumor is pleomorphic adenoma, and the most frequent malignant tumor is mucoepidermoid carcinoma mc. Pdf sclerosing mucoepidermoid carcinoma of the parotid gland. This is a patient with surgical stage t1, clinical n0, lowgrade parotid mucoepidermoid carcinoma. Mucoepidermoid carcinoma of the right parotid gland occ openi. After 4 months, extirpation of the mass was done and the histologic examination unexpectedly revealed a mucoepidermoid carcinoma of the parotid gland. Mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland.
Carcinomatous components can be represented by squamous cell carcinoma the most common 1820, oncocytic carcinoma, adenocarcinoma, undifferentiated carcinoma and mucoepidermoid carcinoma mec 2125. They contain three cellular elements in varying proportions. Advanced stage and highgrade tumors are significant predictors of decreased survival. Salivary gland cancer is diagnosed in 23 individuals per 100,000 people each year, and 3035% of these are mucoepidermoid carcinomas. Role of intraparotid node metastasis in mucoepidermoid. Mucoepidermoid carcinoma of the major salivary glands. Adjuvant treatment for parotid mucoepidermoid carcinoma. Although mucoepidermoid carcinoma of the parotid gland is the most common parotid gland malignancy, it is still a rare tumor with a lack of large populationbased studies. Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland xingyu niu1, qigen fang2 and fei liu1 abstracts background. Mucoepidermoid carcinoma an overview sciencedirect topics. Mucicarmine staining is one stain used by pathologist for detection. Mucoepidermoid carcinoma of salivary glands radiology. The second most common minor salivary gland tumour 1240% globally is mucoepidermoid carcinoma.
Mucoepidermoid carcinomas are the most common type of salivary gland cancer. Mucoepidermoid carcinoma of the right parotid gland occurred in a young girl. Occasional focal sebaceous cells, goblet type cells, oncocytic change, inflammatory reaction to extravasated mucin or keratin. They develop less often in the submandibular glands or in minor salivary glands inside the mouth. Mucoepidermoid carcinoma mec of the salivary gland is believed to arise from pluripotent reserve cells of the excretory ducts that are capable of differentiating into squamous, columnar, and mucous cells. Distant metastasis of the parotid mucoepidermoid carcinoma is very rare, and it usually occurs to the lungs, bones and liver. Aug 01, 2014 mucoepidermoid carcinoma is more frequent in females, occurs in the fifth decade of life and is usually found in the parotid gland. Treatment for salivary gland tumors often involves surgery. Treatment and survival outcomes based on histologic. Pdf mucoepidermoid carcinoma of the thyroid gland irfan.
It typically disseminates to the regional lymph nodes and surrounding soft tissues. Treatments for salivary gland tumors may also include radiation therapy and chemotherapy. Mucoepidermoid carcinoma arising in warthin tumor of the parotid gland is an extremely rare entity. Minor salivary gland tumours account for 1015% of all salivary gland neoplasms and are usually malignant.
We describe our experience of mucoepidermoid carcinoma arising in warthins tumor of the parotid gland in a 64. Mucoepidermoid carcinoma what is, treatment, survival rate. Mucoepidermoid carcinoma is a type of cancer of the salivary glands. Mucoepidermoid carcinoma is graded based on how abnormal the cancers look when subjected to a microscope. Overall, mucoepidermoid carcinomas account for 1,5. Mucoepidermoid carcinoma arising in warthins tumor of the. Mucoepidermoid carcinoma in a minor salivary gland in a child. Apr 15, 2018 pediatric patients in the surveillance, epidemiology, and end results database were included from 1973 to 2014 based on a diagnosis of mucoepidermoid carcinoma of the parotid gland using the international classification of diseases for oncology, third edition codes. Mucoepidermoid carcinoma mec comprises 510% of all salivary gland tumors and mainly involves the major salivary glands. Mucoepidermoid carcinoma in warthin tumor of the parotis. In 1945, stewart and colleagues introduced the term mucoepidermoid to define. Pdf ataxia telangiectasia and mucoepidermoid carcinoma of.
Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac, and thyroid gland. Prognostic factors for parotid mucoepidermoid carcinoma mec usually include disease grade, tumor stage, node stage, perineural invasion, and lymphovascular invasion. Bidari zerehpoosh f, et al 282 iranian journal of otorhinolaryngology, vol. Mucoepidermoid carcinoma of the parotid gland is very rare in children. The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. Has the management of pediatric mucoepidermoid carcinoma of. Mucoepidermoid carcinoma incidence is about 16% of minor salivary gland tumours, second to adenoid cystic carcinoma. The diagnosis of mec is based on the identification of three cell types, which occur in varying proportions. Sclerosing mucoepidermoid carcinoma of the parotid gland.
Warthinlike mucoepidermoid carcinoma of the parotid gland. Among the major salivary glands, the parotid gland is most commonly involved. Although mucoepidermoid carcinoma mec accounts for carcinoma incidence is about 16% of minor salivary gland tumours, second to adenoid cystic carcinoma. Salivary gland tumors symptoms and causes mayo clinic. Mucoepidermoid carcinoma of the soft palate salivary gland. Mucoepidermoid carcinoma the salivary glands are those glands whose primary function is to produce saliva. Rajan mariappan 2004 sclerosing mucoepidermoid carcinoma of the parotid gland. Pdf mucoepidermoid carcinoma in warthin tumor of the. Diagnosis and management of malignant salivary gland tumors of the parotid gland. Pdf mucoepidermoid carcinoma mec is the most common malignant neoplasm of the major salivary glands, accounting for 15.
Mucoepidermoid carcinoma in warthin tumor of the parotid gland article pdf available in archives of medical science 1. Since then, they have become well recognized as a common salivary gland neoplasm, accounting for approximately 35% of all. A rare case of mucoepidermoid carcinoma of parotid with. Pdf largest mucoepidermoid carcinoma of parotid gland in the. Like most malignant neoplasms of the lacrimal glands, patients with mucoepidermoid carcinoma typically present with painful proptosis due to rapid growth of this infiltrative lesion with bony scalloping or. Mucoepidermoid carcinoma occurred in the parotid gland in 196 cases. Mucoepidermoid carcinoma mec of the thyroid gland either primary or metastatic is extremely rare. Mucoepidermoid carcinoma mec is the most common histologic subtype, comprising 50% of all parotid malignancies. Ask the experts mucoepidermoid carcinoma of the parotid gland. Jun 19, 2015 carcinomatous components can be represented by squamous cell carcinoma the most common 1820, oncocytic carcinoma, adenocarcinoma, undifferentiated carcinoma and mucoepidermoid carcinoma mec 2125.
Recurrent mucoepidermoid carcinoma of parotid with facial. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Grade 1 also referred to as low grade or well differentiated cancers may appear like a normal salivary gland cells. Mucoepidermoid carcinoma mucoepidermoid carcinoma of the lacrimal gland is rare, representing only 1% of all lacrimal gland neoplasms. However, the palate is a frequent site when it occurs in the minor glands. Salivary gland malignancies account for pdf available in archives of medical science 1. It is most commonly found in the major salivary glands parotid but may also present in the minor salivary glands.
Lowgrade mucoepidermoid carcinoma of salivary gland. Mucoepidermoid carcinoma of the salivary gland is one of the differential diagnoses. Mucoepidermoid carcinomas in the major salivary glands were scored and graded. Mucoepidermoid carcinoma is the most frequently diagnosed malignancy of the salivary gland. Cytologic diagnosis was mis leading in 70% of reported cases table 1.
Oct 26, 2018 salivary gland tumors most commonly occur in the parotid gland, accounting for nearly 85 percent of all salivary gland tumors. Mucoepidermoid carcinomas are seen throughout all adult age groups, but are most common in middle age 3565 years of age 5. Clinical stage and histologic grade are the main prognostic factors. The treatment may also depend upon the stage, overall health, age, and grade of the tumor.
Department of otorhinolaryngology, head and neck surgery, university of gottingen, gottingen, germany. By grading you will have an idea how fast it will grow and spread. June 2017 includes ptnm requirements from the 8th edition, ajcc staging manual. Mucoepidermoid carcinoma mec is the most common malignancy of the major and minor salivary glands, comprising 34% of salivary gland malignancies. Mec mainly occurs in the parotid gland, along with minor glands being the second common site, particularly in palate. Salivary glands neoplasms represent a rare and diverse group of tumors with different characteristics. A combination of surgery, chemotherapy, and radiation therapy are used to treat mucoepidermoid carcinoma of salivary gland. Recurrent mucoepidermoid carcinoma of parotid with facial tics report of an unusual case published.
Through a long followup period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas. The kaplanmeier estimated cancerspecific survival rates at 5, 15, and 25 years were 98. In the face of small, lowgrade cancers, the risk of lymph. Jun 18, 20 mucoepidermoid carcinoma is a type of cancer of the salivary glands. The mass was resected and shown to be a mucoepidermoid carcinoma. Although mucoepidermoid carcinoma mec accounts for of all tumors of the salivary gland, it constitutes approximately 30% of all malignant tumors of the salivary gland. Mucoepidermoid carcinoma of the major salivary glands goode. Nov 29, 2018 how is mucoepidermoid carcinoma of salivary gland treated.
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